CAS No.: 1007573-18-3
N-((3,5-Difluoro-3'-(1H-1,2,4-triazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-inden-2-amine Catalog No. CSN19796
Synonyms: GSK-1521498;GSK-1521498B
GSK-1521498 is a μ-opioid receptor antagonist. It has been shown to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating, in animals and humans.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00976105 Obesity Phase 1 Completed - United Kingdom ... more >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Collapse << NCT01195792 Obesity Phase 2 Completed - United Kingdom ... more >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ GSK Investigational Site Birmingham, West Midlands, United Kingdom, B15 3ES GSK Investigational Site London, United Kingdom, NW10 7EW Collapse << NCT01738867 Alcoholism Phase 1 Completed - United Kingdom ... more >> GSK Investigational Site Cambridge, United Kingdom, CB2 2GG Collapse << - 更多
- 参考文献
- [1] Ripley TL, Sanchez-Roige S, et al. The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep;232(18):3431-41.
- [2] Kelly E, Mundell SJ, et al. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Psychopharmacology (Berl). 2015 Jan;232(1):305-14.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1007573-18-3 | 储存条件 |
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| 分子式 | C24H20F2N4 | 运输 | 蓝冰 | |
| 分子量 | 402.44 | 别名 | GSK-1521498;GSK-1521498B |
